Sex and Cialis

By David Jay Brown

 Cialis (tadalafil) is a pharmaceutical in the same class of drugs as  Viagra, and like Viagra, is also prescribed for erectile dysfunction.  Cialis is often hailed as a kind of “super-Viagra” because it has a  similar success rate to Viagra, but it generally lasts around nine times  longer.

 Cialis can help men with erectile difficulties achieve erections for up  to 36 hours, which allows couples to be much more spontaneous with their  sexual intimacy than they can be with Viagra, which only lasts around 4  hours. Also, unlike Viagra, Cialis does not have to be taken on an empty  stomach, and it does not cause blueish-tint shifts in color vision like  Viagra sometimes does.

 Cialis and Viagra actually work by similar mechanisms . Both drugs are  known as “PDE5 inhibitors”. This means that they inhibit the effects of  an enzyme called “Phosphodiesterase type 5” (PDE5). PDE5 causes  erections to droop by degrading another enzyme called “guanosine  5-triphospate” (cGMP), which is triggered by nitric oxide (the primary  neurotransmitter responsible for causing erections in men) during sexual  arousal.

 Nitric Oxide triggers the release of cGMP, which relaxes muscles in the  penis and allows blood to flow into the paired erectile chambers (known  as the Corpora Cavernosa) that run along the length of the organ. By  inhibiting the effects of the enzyme PDE5, as Cialis and Viagra do, one  extends the initial penis-stiffening effects of nitric oxide.

 Cialis has been the subject of 22 clinical studies with more than 4000  men who suffer from erectile dysfunction. It was found that the  erection-enhancing effects of the drug generally last between 24 and 36  hours. Cialis was reported to improve erections in 81% of men who had  previously experienced impotence, with 75% of intercourse attempts  successful.

 The most common side effects reported with Cialis were headaches, back  aches, general muscle aches, and an upset stomach. Around 1 in 7 people  taking Cialis experienced a headache, and around 1 in 8 experienced  dyspepsia (indigestion). The side-effects were usually reported to occur  between 12 and 24 hours after taking the drug, and generally went away  after a few hours. In studies that were done with Cialis most men  reported that the benefits outweighed the side-effects, and the majority  of men who experienced the side-effects continued to use the drug.

 Cialis is a prescription drug in the United States. Men should not take  Cialis if they are taking nitrate medication for angina or  alpha-blocking drugs. Also, men who take Cialis should not drink  grapefruit juice because it could make side-effects (such as headache  and dyspepsia) more likely.

 Like Viagra, Cialis only helps to facilitate erections when the man is  sexually aroused. However, on rare occurrences erections with Cialis may  sometimes last longer than one wishes. If this occurs for more than two  or three hours (a painful condition know as “priapism”) one should seek  medical attention immediately, as permanent damage to the blood vessels  in the penis can occur.

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